The Federal agency responsible for regulating interstate shipments of hazardous materials is?

The Federal agency responsible for regulating interstate shipments of hazardous materials is the Department of Transportation (DOT).

The Department of Transportation’s role in regulating hazardous materials is a critical component of the national emergency management framework. Within the Incident Command System, the DOT’s regulations and guidelines directly impact how hazardous materials are transported and handled during emergencies. For example, in the event of a hazardous material spill on an interstate highway, the response protocols, safety measures, and containment strategies employed by emergency responders are influenced by DOT regulations.